Formulation and evaluation of Fast Dissolving Tablets of Lamivudine to prevent Mother to Child Transmission

Abstract

A fast dissolving tablet can be defined as a solid dosage form that can disintegrates into smaller granules which
slowly dissolve in the mouth. The disintegration time for fast dissolving tablet varies from a few seconds to more
than a minute depending on the formulation and the size of the tablet. A fast disintegrating or dissolving system or
tablet can be defined as a solid dosage form that can disintegrate or dissolve within 30 seconds, in the oral cavity
resulting in a solution or suspension without administration of water. The fast disintegrating tablets are synonymous
with fast dissolving tablets; melt in mouth tablets, rapimelts, Porous tablets, Orodispersible, quick dissolving or
rapidly disintegrating tablets. Patient may suffer from tremors therefore they have difficulty to take powder and
liquids. In dysphasia physical obstacles and adherence to an esophagus may cause gastrointestinal ulceration.
Swallowing of solid dosage forms like tablet and capsules and produce difficulty for young adult of incomplete
development of muscular and nervous system and elderly patients suffer from dysphasia. Liquid medicaments
(suspension and emulsion) are packed in multidose container; therefore achievement of uniformity in the content of
each dose may be difficult. Buccal and sublingual formation may cause irritation to oral mucosa, so patients refused
to use such medications cost of products is main factor as parenteral formulations are most costly and discomfort.