Optimization of cross linked tragacanth and comparison of drug release rate profile with synthetic superdisintegrants on metoclopramide orodispersible tablets

Abstract

Fast dissolving dosage forms can be disintegrated, dissolved, or suspended by saliva in the mouth. This fast dissolving tablet disintegrates instantaneously when placed on tongue and releases the drug dissolves or disperses in the saliva. Fast dissolving tablets are useful in patients, like pediatric, geriatric, bedridden, or mentally disabled, who may face difficulty in swallowing conventional tablets or capsules leading to ineffective therapy, with persistent nausea, sudden episodes of allergic attacks, or coughing for those who have an active life style. Present investigation is to optimize the cross linked tragacanth as natural super disintegrants and comparison of drug release profile with SSG, Crospovidone by direct compression using metoclopromide hydrochloride. From the dissolution profiles, Optimized formulation found to be C₃, 1:0.8 in ratio of Dry tragacanth powder and epichlorhydrin. Different drug formulations are prepared by direct compression. From the drug release profiles it is concluded that formulation with 4% of optimized CLT by direct compression have highest drug release of 95.39% at the end of 15mins when compare to other formulations and natural superdisintegrants have more efficiency than synthetic superdisintegrants.