Formulation and In-Vitro evaluation of fast dissolving tablets of telmisartan

Abstract

Telmisartan is a Anti-hypertensive drugs which is insoluble in water, hence the drug may be slowly or incompletely dissolves in the gastro-intestinal tract. So the rate of dissolution and therefore its bioavailability is less (bioavailability 42%). In the present study an attempt has been made to prepare Fast Dissolving tablets of Telmisartan by using Superdisintegrants– Cross carmellose sodium, Microcrystalline cellulose and sodium starch glycolate, level of addition to increase the rate of drug release from dosage form to increase the dissolution rate and hence its bioavailability. The tablets were prepared by Direct Compression methods and the prepared blend and tablets were evaluated for their physicochemical properties and In-Vitro dissolution study. The evaluation studies were performed such as Weight Variation, Thickness, Hardness, Disintegrating Time, Wetting Time, and In-Vitro Drug Release. The Disintegration time of Fast Dissolving tablets were increased by the addition of concentration of Superdisintegrants.