Formulation and evaluation of aceclofenac fast dissolving tablets

Abstract

The present investigation deals with development of fast dissolving tablets of aceclofenac to produce the intended benefits. Fast dissolving tablets of aceclofenac were prepared using superdisintegrants crospovidone, croscarmellose sodium and sodium starch glycolate and surfactant sodium lauryl sulfate, using the direct compression method. The tablets prepared were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in vitro disintegration time and in vitro dissolution time. The tablets disintegrated within 18 to 49 seconds. Almost 90% of drug was released from all formulations within 15 min. Stability studies of the tablets at 40±2°/75%±5% RH for 3 months showed non significant drug loss. The formulation containing 6% of croscarmellose sodium was found to give the best results. Apart from fulfilling all official and other specifications, the tablets exhibited higher rate of release.