Formulation and evaluation of oral disintegrating tablet of oxcarbazepine

Abstract

A fast dissolving tablet was prepared by using various Ingredients like Crosepovidone , Mannitol Sodium lauryl sulphate (SLS) , Magnesium stearate was taken in different concentration (5-10% 50%, 2-6%, 1%,).Chemical incompatibility studies confirmed that there is no interaction between drug and excipients used in the formulations. All the batches are prepared by direct compression method. Effect of disintegrants concentration on the disintegration behavior was evaluated, and all the tablets were evaluated for hardness, friability, weight variation, water absorption ratio, dissolution, and assay. Among the all preparations F8 emerged as the best formulation and showed maximum dissolution rate.