Synthesis of l-Aryloxy-Cyclohexane-2,3-Diols: A Novel Approach for Potential Antidiabetic Agents

Abstract

The synthesis of l-aryloxy-cyclohexane-2,3-diols represents a novel approach for developing potential antidiabetic agents. This study focuses on the epoxidation of l-phenoxy-2-cyclohexene, followed by selective cleavage of the resulting epoxy ring to yield stereochemically defined diols. The synthesized compounds were characterized using NMR spectroscopy, confirming their structural integrity and stereochemistry. The biological activity of these diols was evaluated, showing promising potential as antidiabetic agents. These findings suggest that l-aryloxy- cyclohexane-2,3-diols could serve as lead structures for the development of new therapeutic agents targeting type-2 diabetes.