The possible protective role of Thymus vulgaris against hepatotoxicity and nephrotoxicity of cyclosporine A

Abstract

In this study, we investigated the possible protective role of the thymus
vulgarisextract in reducing hepatic and renal toxicity of cyclosporine A
in rabbits. Levels of total protein and albumin showed a significant
depression after treatment with cyclosporine A compared to the control.
Levels of bilirubin increased significantly after treatment with
cyclosporine A compared to control. Levels of ALT, AST, ALP, ACP
and LDH showed a significant increase after treatment with cyclosporine
A compared to the control. Results showed that Thymus vulgaris extract
had a protective role by alleviating the toxic effects of cyclosporine A.