Development and Optimization of Telmisartan-loaded Polymeric Nanoparticles: A Novel Approach for enhanced drug delivery and sustained release

Abstract

Advanced drug delivery systems have gained much attention lately, especially in improving the bioavailability and therapeutic efficiency of poorly water-soluble drugs. Telmisartan is known as an extensively applied antihypertensive drug, which shows relatively low solubility and bioavailability and limits its clinical efficiency. In this paper, for solubility and stability enhancement together with sustained drug release, designed and optimally prepared polymeric nanoparticles (NPs) have been used as telmisartan delivery forms. A PLGA-based nanoparticulate drug delivery system with biodegradability was constructed to ensure better controlled drug release and pharmacokinetic performance. This has been done with the use of different formulation techniques, such as solvent evaporation and nanoprecipitation followed by systematic screening and statistical optimization using Plackett-Burman and Box-Behnken designs.