Preparation, optimization and characterization of PLGA nanoparticle

Abstract

Aim of present study is to prepare PLGA nanoparticle. Nanoparticles were prepared by double emulsification solvent evaporation method. Various formulation and process variable which could affect the preparation and properties of nanoparticles. These formulation variables were identified and optimized to get uniform preparation with highest encapsulation efficiency. Formulation variables include amount of drug, polymer concentration and stabilizer concentration and process variables include stirring speed, stirring time and sonication time. All these parameter were optimized by taking the effect of variable on particle size, polydispersity index and encapsulation efficiency.