Preparation and evaluation of itraconazole liposome using ether injection solvent evaporation method

Abstract

Itraconazole is an antifungal drug, is a frequently and widely used drug to treat fungally infected skin. The presently available ITZ formulations for topical use, with their traditional design formulation pattern however, maintaining their place in the amount of dermatologists but now evoked the thought of their improvement in the light of the latest developments. Liposomes with their potential promise to improve the transportation of ITZ to make it better localized and acted upon the micro-organisms have been valued in the present investigation. A facilitated bio-friendly vehicular effect, active hydrating conditions and a provision for a solubilized status of drugs are some obvious advantages of these vesicular systems. The work on the development of liposomes of ITZ was taken-off by focusing on the studies to gain the knowledge on drug-characters (i.e., drug profile) and estimation techniques. The techniques to determine the drug concentration during various studies were studied out (e.g., drug entrapment, in-vitro characterization and evaluation). A diffusion medium for drug release was studied for ITZ. From the results obtained it was concluded that out of four formulations prepared, F3 was optimized formulation.