Nanosuspension: A Promising Approach to Improve Solubility, Dissolution Rate and Bioavailability of Poorly Soluble Drug

Abstract

Solubility is a critical element in pharmacological efficacy of drug regardless of the method of administration. The nanosuspension technology can improve the drug's solubility and bioavailability. The fact that many newly discovered drugs are water insoluble and thus show poor absorption and bioavailablity. These low solubility drugs can now be administered using nanosuspension formulation. Commercially available technologies such as high pressure homogenization, media milling, emulsification, and melt emulsification are frequently used to make nanosuspensions. Post-processing techniques such as solidification and surface modification are utilized to provide certain features to advanced therapies. Drugs like Itraconazole, Simvastatin, and Carbamazepine, which are poorly soluble in both aqueous and nonaqueous environments and are categorized as BCS class II make the issue even more complicated. Formulation as a nanosuspension is an appealing and promising solution to these issues. This review article discusses about the advantages, disadvantages, method of preparation, characterization, and applications of nanosuspensions.