Formulation of Modified Release Matrix Tablets of Salbutamol Sulphate Using Accelerating Agents

Abstract

The present study was focused to develop and evaluate the matrix tablets of salbutamol containing cellulose derivative and natural gums as release modifying polymer. In vitro release studies showed that formulation F-8 which contained Xanthan gum: Guar gum: HPMC (2:1:3) was chosen as optimized formulation because it can sustained release till 8 hours to release 96.84±1.57 percent of drug.