Formulation Development and Evaluation of Mefenamic Acid Floating Tablet Using Natural Polymer

Abstract

Floating tablets of Mefenamic acid were developed with different concentrations
of guar and Xanthan gum by direct compression methodology. The parameters
such tapped density, bulk density, Carr’s index, Hausner’s ratio and angle of
repose was found to be in the range and the thickness, weight, variation,
hardness, friability of the tablets were found to be in the rang Tablets containing
higher amount of guar gum & Xanthan gum usually showed longer total floating
time. It ranged from 06 to 6.5 h. At the end of 6 h, F4 showed the best drug
release 93.20%. F1, F2, F3, F5, and F6 showed 90.3, 91.7, 89.29, and 83.3% F6
showed the foremost effective sustained release behavior (73.2%) because of the
polymer concentration was increased with increased viscosity grade, the
percentage drug release got decreased resulting in a sustained drug release
pattern over a period of more than 6.5h due to enhance Floatation, Based on
present study it absolutely was concluded that floating tablets of mefenamic acid
can increase the bioavailability additionally as gastric residence time, and so
batter patient compliance may be achieved. It can be concluded that floating
tablets are often used as a SR matrix. Due to their superior characteristics.