Formulation and Evaluation of Oro Dispersible Tablets of Ondansetron Hydrochloride by Direct Compression using Superdisintegrants

Abstract

The objective of the present investigation was to prepare oro dispersible
tablets of ondansetron hydrochloride, because of its application in emesis
condition, fast onset of action and avoidance of water is highly desirable.
Tablets were prepared by direct compression using sodium starch
glycolate and croscarmellose as superdisintegrants, as the combination of
these two agents gives better disintegration of the tablet. Microcrystalline
cellulose was used as diluent and mannitol, mint flavor, sodium
saccharine to enhance the organoleptic properties of tablets. The tablets
were evaluated for weight variation, mechanical strength, in vitro
disintegration time, in vivo disintegration time, wetting time, and drug
release characteristics. Hardness and friability data indicated good
mechanical strength of tablets.
The results of in vitro disintegration time and in vivo disintegration time indicated that the tablets
dispersed rapidly in mouth within 3 to 5 seconds. Dissolution study revealed faster release rate of
ondansetron hydrochloride from the tablets as compared to pure drug and marketed conventional tablet
formulation of ondansetron hydrochloride. It was concluded that superdisintegrants addition technique is
a useful method for preparing oro dispersible tablets by direct compression method