Formulation and evaluation of mouth dissolving tablets of atenolol

Abstract

Attempts were made to prepare mouth-dissolving tablets of atenolol by direct compression method with a view to enhance patient compliance. The two super disintegrants used in this study were croscarmelose sodium and sodium starch glycolate. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time and dissolution study. Using the same excipients, the tablets were also prepared, without disintegrants and were evaluated in the similar way. From the results obtained, it can be concluded that the tablet formulation (A4) showed the promising formulation. Also the hardness, friability, disintegration time and dissolution rate of prepared tablets were found to be acceptable according to standard limits.