Mucoadhesive buccal drug delivery system

Abstract

Within the oral mucosal cavity, the buccal region offers an adorable route of administration for systemic drug delivery. Among the various transmucosal sites available, mucosa of the buccal cavity was found to be the most convenient and easily approachable  site for the delivery of therapeutic agents for both local and systemic delivery as retentive dosage forms. Mucoadhesion can be defined as a state in which two components, of which one is of biological origin are held together for extended periods of time by the help of interfacial forces. The mucosa has a rich blood supply and it is relatively permeable. Buccal dosage forms will be reviewed with an emphasis on bioadhesive polymeric based delivery systems. The mucoadhesive interaction is explained in relation to the structural characteristics of mucosal tissues and the theories & properties of the polymers. Degree of mucoadhesion bonding is influenced by various polymer-based properties. Evolution of such mucoadhesive formulations has transgressed from first-generation charged hydrophilic polymer networks to more absolute second-generation systems based on lectin, Thiol and various other adhesive functional groups.