Formulation and Evaluation of Transdermal Patch of Glibenclamide

Abstract

The plan of the present research study was to prepare Glibenclamide
transdermal patches and to study the effect of two polymer combination
and polymer ratios on physiochemical parameters including in-vitro drug
release profile. Glibenclamide transdermal patches were prepared using
Chitosan is the main natural polymer and Hydroxy propyl methyl
cellulose (HPMC) in different ratios. Dibutylphthalate was used as a
plasticizer and oleic acid used as permeation enhancers which were
prepared by solvent casting method. The prepared formulations were
evaluated for various in vitro parameters like Thickness, Weight
variation, Folding endurance, Moisture absorption, Moisture loss, Drug
content, Drug permeation, In-vitro drug release studies were performed
by using Franz diffusion cells. The FT-IR studies revealed no interaction
between drug and polymers. Chitosan and HPMC is better formulation
for control release of drug up to 8 hrs of time.
However the in vitro drug release of the best formulation F4 follows zero order kinetic and the
mechanism of the present study encourage that the Glibenclamide transdermal patch can be used as
controlled drug delivery system and frequency of administration can be minimized.