Formulation and Evaluation of Sustained Release Matrix Tablets of Captopril

Abstract

The present investigation of this study was to develop Captopril SR
matrix tablets that provide complete drug release that starts in the
stomach to rapidly alleviate the symptoms and continues in the intestine
to maintain its effect. Drug-polymer compatibility studies by FTIR gave
confirmation about their purity and showed no interaction between drug
and selected polymers. Various formulations were developed by using
release rate controlling and gel-forming polymers like HPMC K100,
ethyl cellulose and sodium CMC by direct compression method.
Cellulose derivatives have been widely used in the formulation of
hydrophilic matrix tablet for sustained drug delivery. From among all the
developed formulations, F7 formulation sustained the drug release for
longer period of time as compared to other formulations. So, F7 was
selected as the best formulation. The best formulation was found to be
stable during stability studies for two months. Thus, best formulation
satisfied physicochemical parameters and in vitro drug release profile
requirements for a sustained drug delivery system.