Enhancement of bioavailability and gastric residence time of cephalexin by hydrodynamically balanced system

Abstract

Oral delivery of drugs is by far the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulation etc. From immediate release to site specific delivery, oral dosage forms have really progressed. More than 50% of the drug delivery systems available are to be administered through oral route. During the last decade, many studies have been performed concerning the sustained release dosage forms of the drug, which have aimed at the prolongation of gastric emptying time (GET). Oral sustained release gastro retentive dosageforms (GRDFs) offer many advantages for those acting locally in the stomach, improving the bioavailability of the medication. Floating Drug Delivery System is one amongst the GRDFs used to achieve prolonged gastric retention time. Cephalexin is in a group of antibiotics and is used to fight against gram positive infections in the body. In this present study to enhance the gastric retention of the Cephalexin, it is formulated as effervescent floating dosage form by direct compression method. The polymers like HPMC K4M, HPMC K15M, HPMC K100M and Sodium bicarbonate are used. From the results of dissolution profile it was conformed that the antimicrobial action of Cephalexin may be increased in the stomach due to increase retention time and absorption by using HPMC K100M (F9 formulation) than other formulations. Drug release of F9 was found to follow first order kinetic model and the mechanism of the drug release was found to be diffusion controlled process.