Evaluation of dissolution enhancement of lovaststin by solid dispersion technique

Abstract

The areas of current interest which have a significant impact on clinical therapy are enhancement of dissolution rate and bioavailability of insoluble and poorly soluble drugs. Lovastatin is an antihyperlipidimic drug, which inhibits the production of cholesterol in liver is poorly water soluble drug. Due to poor solubility of drug, its bioavailability rate is limited by drug dissolution. In the present study, an attempt has been made to increase the solubility and dissolution of Lovaststin by solid dispersion technique using hot melt, solvent evaporation and kneading method with Poloxamer F-68. Effects of various parameters such as type of carrier system used, drug: carrier ratio were studied. The evaluation of solid dispersion was done by solubility and dissolution studies. Improvement in dissolution of drug was observed in all the solid dispersions as compared to pure drug. The dissolution rate of Lovaststin was directly proportional to increment in proportion of the carrier. Pure Lovaststin showed only 61% drug release in 1 hour where as the Solid dispersion prepared by solvent evaporation method using Poloxamer F-68 showed faster in vitro drug release incomparision to pure drug (plain tablet) and marketed formulation.