Solubility enhancement of antihypertensive agent by solid dispersion technique

Abstract

The present study was aimed to increase the solubility of the poorly water soluble drug Telmisartan by using polymers like Gelucire 43/01, Poloxamer 407, PVP K-30 and HPMC E4 and PEG 6000. Solid dispersions were prepared by fusion method. Saturation solubility studies, in-vitro dissolution of pure drug, physical mixtures and solid dispersions were carried out. All the polymers were found to be effective in increasing the dissolution rate of Telmisartan in solid dispersions when compared to pure drug. Also FT-IR spectroscopy, differential scanning calorimetry and X-ray diffractometry studies were carried out in order to characterize the drug and solid dispersion.