International Journal of Pharmacy & Life Sciences Volume 11 Issue 12: Dec. 2020 7 1 3 9 [[ Formulation and Evaluation of Pantoprazole Solid Dispersion Tablet

Abstract

The term solid dispersion refers to a bunch of solid merchandise consisting of a minimum of two completely different parts, usual a deliquescent matrix and a hydrophobic drug. Additionally to bioavailability improvement, a lot of recent analysis on solid dispersion systems was directed towards the event of extended-release indefinite quantity forms. Data regarding behavior of solid dispersions throughout preparation, storage and dissolution will facilitate to tackle these issues. An intensive understanding of processes that happens place on the molecular level could be a requirement for rational and a lots of economical style of solid dispersions. However, development of solid dispersions has typically been a trial-and-error approach. Solid dispersion ready by physical mixture technique were subjected to dissolution study. Two freelance variables selected were HPMC E5 and PVP K30 in the ratio of 1:1, 1:2 and 1:3. The target achieved and these findings recommended that the preceding technique may be utilized with success for improvement of solubility profile and stability of Solid dispersions of poor water soluble drugs.