Vishwas Hardiya*and Monika Mann

Abstract

The drug allopurinol is in crystalline form which is converted to amorphous form to enhance the solubility by solid dispersion .This might be due to solubilising effect of carriers or amorphous state of the drug in solid dispersion or entrapping the drug in molecular state by the carrier.Maltose and Sucrose are used as a carrier in the formulation of solid dispersion in different concentration such as 1:1, 1:3, 1:5. As the concentration of the carriers increased, it also improved the solubility of the drug. The nature and amount of carrier used plays an important role in the enhancement of the dissolution rate. The increased solubility and dissolution rate of allopurinol provided the rapid onset of action .The carrier used is easily available , feasible to use and have low cost .Thus the formulation will be the cost effective. From the above study it was concluded that the kneading technique is useful for the preparation of solid dispersion of allopurinol.