Solid Dispersion Preparation of Carvedilol and its Evaluation

Abstract

The present research has two parts preparation and evaluation of the solid dispersion of the said drug carvedilol. The first pat and also the largest part give an account of strategies that can be employed to enhance the bioavailability of the drugs. The emphasis has been given on dispersion of insoluble drugs in soluble polymer matrix and their behavior in the gastrointestinal tract that leads to enhanced absorption of drugs. This part also deals with history, definition, classification, characterization of solid dispersion, advantages and disadvantages, unmet needs and challenges and applications of solid dispersion in dosage forms. Second part contain some evaluation parameter of the solid dispersion, such as drug content, solubility studies.