A Systematic Review on Nanosuspension and its advancements

Abstract

The solubility is the preferential criteria for the medicament to show pharmacological action. A pharmaceutical suspension is a coarse dispersion of insoluble solid particle in a liquid medium. One of the best suitable dosage forms for people who cannot take solid dosage forms. It contain solvents, buffering agent, preservative, antioxidants, wetting agent, anti-foaming agent, suspending agent and flavouring agent. Suspension dosage form incorporate effective distribution of lipophilic drug; mask a bitter taste, avoid the use of cosolvents and provide resistance to deterioration of drug due to hydrolysis, oxidation or microbial activity. In addition, nanosuspension is the novel and recent advancement in enhancing aqueous solubility of weakly soluble drugs. It not only increases aqueous solubility but increases bioavailability as well. As a result of the significant improvement in bioavailability, the flexibility for surface modification and mucoadhesion for drug targeting have significantly expanded the scope of this novel formulation technology. Suspension allows for the absorption drug relatively higher than any other solution dosage forms. Different method of preparation are used with a solvent, suspending agent (HPMC and Methyl Cellulose) and Surfactant (Tween-80, and SLS). Introduction, preparation techniques, characterisation, and applications of the nano suspension are covered in this review article.