Evaluation of wound healing activity of herbal drug combination of Rubia cordifolia, Centella asiatica,Terminalia belerica,Plumbago Zeylanica and Withania somnifera

Abstract

A herbal drug combination of Rubia cordifolia, Centella asiatica, Terminalia belerica,Plumbago zeylanica and Withania somnifera was evaluated for wound healing activity, on excision wound of albino rats. Wound healing activity of the plant was evaluated by formulating the drug in ointment dosage form and then compared with a marketed formulation (Soframycin cream) as reference drug. The parameters studied includes the percentage closure of excision wound, period of epithelization. The herbal drug combination has been observed to promote healing of wounds in animals. The results of analysis were validated statistically and by recovery studies.