Wound dressing application of chitosan based bioactive compounds

Abstract

Generation of immense quantity of underutilized marine processing byproducts has long been recognized as wastes and greater efforts were given to use these materials in various applications. With a great number of researches on these byproducts, some biologically active compounds were identified and implicated to the useful compounds for human utilization. Chitosan and silver nanoparticle have proven wound healing properties individually. As both have wound healing property, the combination of these two may show improvement in wound healing activity. Thus, the composite were evaluated for various in vitro evaluation tests to ascertain the applicability of prepared combination for wound healing activity. These films were evaluated for water absorption capacity, antibacterial activity, tensile strength and in vivo wound healing studies by excision wound model using albino rats. The drug loaded films have shown significant difference in water absorption capacity and antibacterial activity when compared to optimized blank composite film. There was no significant difference in tensile strength of drug loaded films when compared to blank composite films. Percentage of wound contraction was better for wounds treated with gentamycin loaded composite film than blank composite film. With the above results, it was concluded that gentamycin loaded Chitosan-Cellulose-Silver nanoparticle composite(C-Ch-Ag) films had shown more wound healing properties than Chitosan-Cellulose-Silver nanoparticle blank composite film.