Synthesis, characterization and anthelmintic activity of 4-[2'-(5'-nitro) imidazolyl] benzoyl (n-methyl) amino acid derivatives

Abstract

Compound containing the imidazole ring are very important in living system, such as vitamin B12 and several pilocarpin alkaloids. Condensation of heterocyclic moieties viz nicotinic acid, thiazole, coumarin, quinoline, furan, imidazole etc. with amino acids and peptides resulted in compounds with potent biological activities. Many of the heterocyclic found to exhibit antifungal, antibacterial, cytotoxic, antineoplastic, insecticidal, anti-inflammatory, tyrosinase inhibitory and melanin production inhibitory activities. Imidazoles have been drawn as promising structural units in the field of medicinal chemistry. Introduction of D-amino acids and N-methylation of amino acids like tyrosine, valine, alanine etc enhanced antimicrobial activity. Hence an attempt is made towards the sythesis of 5-nitroimidazolyl-benzoic acid derivative of N-methyl amino acids and peptide using solution phase technique of peptide synthesis. The synthesized amino acid derivatives studied for anthelmintic activity