Cardioprotective effect of grapeseed proanthocyanidin on doxorubicin induced myocardial injury in rats

Abstract

Grapeseed Proanthocyanidin [GSP] seeds possessing a potent antioxidant and cardioprotective properties were evaluated against Doxorubicin induced cardiotoxicity in rats. Intraperitonial injection of DOX [10mg kgˉ¹ /b.wt] administrated once a day for 15 days was revealed by elevated serum creatine phoshokinase [CPK] lactatedehydrogenase [LDH] aspartate transaminase [ASP] alanine transaminase [ALT] HDL cholesterol and triglycerides in comparison of control and associated with increasing levels of myocardial malondialdehyde [MDA] with simultaneously decrease in the level of  glutathione peroxidase [Gpx], glutathione-S transferase [GST] and  glutathione reductase [GR]   daily oral administration of aqueous suspension of GSP seeds extract in the dose of (200 mg\kg\b.wt) for 15 days produced normalization in the serum levels of heart marker enzymes. So the study shows that GSP seeds possess antioxidant and cardioprotective effect.