Synthesis and Evaluation of Antimicrobial Activity of some Sulfur Nitrogen contain Heterocycles

Abstract

The structural and therapeutic diversity coupled with commercial viability of small heterocyclic molecules has fascinated organic and medicinal chemists. So, a great deal of research is carried out in the field of heterocycles containing sulfur and nitrogen, because of their immense biological importance.Research in field of antimicrobial therapy is continuous ongoing & demanding study. Among the several reasons the major ones are the resistance developed by microbes and the emergence and occurrence of newer infections. Hence the search for newer effective antimicrobial agents is imperative. It focuses on the problems of cross resistance & better activity against variety of infections.The main focus of this research work was to synthesize, purify and characterize the thiazole analogs and return for their antimicrobial and antifungal activity. Most of the compounds synthesized showed good antibacterial activity within the series against both Gram - ve and Gram + ve bacteria at 100 μg/0.1 ml concentration.