Biochemical consider on the defensive role of Ginseng in male rabbits

Abstract

Ginseng (Panax ginseng C.A. Meyer) roots have been used for a long time as a traditional medicine in Asian countries for preventive and therapeutic purposes. Ginseng has immune-modulatory anti-tumor antioxidant, and glucose-lowering activities. We have therefore investigate the effects of either 100 mg/kg B.W. doses of ginseng on the levels of biochemical parameters in male New Zealand White rabbits. Animals were orally given 100 mg/kg B.W. doses of ginseng. The tested doses were given to rabbits every other day for 12 weeks. Treatment with ginseng caused significant (P < 0:05) decrease in the concentrations of glucose, plasma asparatate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, lactate dehydrogenase (LDH), gamma glutamyl transferase activity (ɣ-GT), Plasma thiobarbituric acid-reactive substances (TBARS) and bilirubin. Contrariwise, the total protein (TP), globulin and albumin was significantly increased in plasma. Concentrations of urea. But, creatinine, cholesterol, triglycerides (TG), low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) were significantly decreased, while high density lipoprotein (HDL) was increased.