Estimation of Nimesulide using mixed solvency approach

Abstract

Organic solvents are most frequently employed in spectrophotometric
analyses. They may be sources of pollution. Some of them may be toxic
while others may be costlier. Volatility may be a source of inaccuracy in
spectrophotometric estimations. In the present investigation, it was
proposed to solubilize Nimesulide by use of mixed solvency concept.
Nimesulide shows maximum absorbance in the concentration range of
10-50µg/ml at 390 nm. Method of analyses have been validated for
different parameters like linearity, accuracy, precision, LOD and LOQ.
The percent drug estimated in tablet formulation of Batch-I and of BatchII were 100.16±0.260and 99.96±0.283 respectively. The range of percent
recoveries varied from 100.36±0.175 to 101.23±0.371.Sodium Benzoate
and phenol do not interfere above300 nm. The analytical method was
found to be simple, safe (free from toxicity), economic and eco-friendly.