Quantitative estimation of Diclofenac sodium in marketed formulation by using mixed solvency approach

Abstract

Abstract

The proposed method is new, simple, environmentally friendly, accurate, reproducible, precise and validated statistically for simultaneous estimation of diclofenac sodium in bulk drug and tablet dosage form. The optimized methods showed good reproducibility and recovery with standard deviation of < 1.0% and percent relative standard deviation less then 2.0%, standard error in case of recovery studies are satisfactorily low and allow estimation of diclofenac sodium in concentration ranges employed for this purpose in the assay of bulk drug and tablets.