Formulation and evaluation of cephalexin extended release tablets

Abstract

The present investigation deals with development of Hydroxypropyl methylcellulose (HPMC 15cps) based cephalexin extended release (ER) tablet by direct compression method, which can release the drug for six hours at predetermined rate. Different concentration of HPMC 15cps were taken from lower to higher concentration with respect to drug and study their effect on drug release and  evaluate different formulation parameters like bulk density, tapped density, compressibility index, Hausner’s ratio, tablet hardness, friability, uniformity of weight, uniformity of drug content and stability study. The result of extended release tablet formulation F-5 containing 13.3% HPMC 15cps with respect to drug shows drug release in six hours at predetermined rate from other 5 formulation. The dissolution results show that on a higher amount of HPMC 15cps in tablet composition resulted in reduced drug release. The tablets were prepared by direct compression method. Hardness was found to be in the range of 7.54±0.01to 10.24±0.03 kg/cm², the percent friability was in the range of 0.1022±0.02 to 0.3633±0.01 % and tablets showed 97.18±0.48 to 99.78±0.07% of the labeled amount of cephalexin indicating uniformity content. The effect of storage on in vitro release and physicochemical parameters of successful batch was studied and was found to be in acceptable limits.