Development and Characterization of Bilayer tablet of Divalproex sodium

Abstract

In the present work bi-layered tablet of Divalproex sodium were prepared by wet granulation method, using superdisintegrants such as sodium starch glycolate and croscarmellosefor immediate release layer and polymer like HPMC K4M and HPMC K100M for sustained release layer. Best formulations of each layer were selected for bi-layered tablet and bi-layered tablet were prepared. Bi-layered tablet of Divalproex sodium were subjected to hardness, weight variation, friability, drug content uniformity, in vitro drug release and drug polymer interaction