Assessment of various pharmaceutical excipient properties of natural Moringa oleifera gum [Mucoadhesion, disintegration, binder]

Abstract

Plant gums and mucilages are being used due to their abundance in nature, safety and economy. So in The present investigation was an effort to study the suitability of gum obtained from Moringa oleifera as tablet mucoadhesive polymer, disintegrant and binder. This property of the gum was evaluated and compared with standard polymers like Chitosan, HPMC for mucoadhesion. Sodium starch glycolate (SSG), crospovidone for disintegration. Xanthan gum, and Starch for binder study. In this study gum isolated from trunk of Moringa oleifera was studied at different concentrations and conditions. The properties of Moringa oleifera gum were evaluated for solubility, loss on drying, total ash and acid in soluble ash, pH, angle of repose, bulk density, tapped density, carr’s compressibility index and Hausner’s ratio. The physicochemical properties of gum were characterized, by FTIR, DSC, and SEM. The gum disks were prepared for mucoadhesive study and evaluated for mucoadhesive strength, surface pH, swelling index. For disintegration study tablets were prepared by direct compression and wet granulation method with different concentration of gum and evaluated for disintegration time, wetting time. And for binding property the tablets were prepared with different concentration of gum as binder by wet granulation method, and evaluated for hardness, friability, and in vitro release profiles. Studies show that increasing concentration of Moringa oleifera gum decrease disintegration time in disintegration property study, and decrease % cumulative release in binder property study. Results obtained indicated that Moringa oleifera gum performed as good mucoadhesive polymer, disintegrating agent and binder.