Formulation and Evaluation of Mucoadhesive Microsphere Drug Delivery System of Losartan Potassium

Abstract

Drug absorption in the gastrointestinal tract is a highly variable process. Chitosan Mucoadhesive microspheres are promises to be a potential approach for gastric retention enhances the bioavailability and controlled delivery of various therapeutic agents. Significant attempts have been made worldwide to explore these systems according to patient requirements, both in terms of therapeutic efficacy and compliance. Chitosan Mucoadhesive microspheres as gastro retentive dosage forms precisely control the release rate of target drug to a specific site and facilitate an enormous impact on health care. These systems also provide tremendous opportunities in the designing of new controlled and delayed release oral formulations, thus extending the frontier of futuristic pharmaceutical development. Furthermore, recent innovations in pharmaceutical investigation will surely provide real prospects for establishment of novel and effective means in the development of these promising drug delivery systems. In-vitro data obtained for Chitosan mucoadhesive microspheres of Losartan potassium showed good incorporation efficiency, good buoyancy and prolonged drug release. Microspheres of different size and drug content could be obtained by varying the formulation variables. From the results it can be concluded that the drug release from the floating microspheres controlled by the polymer proportion. Prepared formulation showed best appropriate balance between buoyancy and drug release rate.