Formulation and characterization of clarithromycin based nanoparticulate drug delivery system

Abstract

The aim of the present work is to prepare and evaluate the oral mucoadhesive sustained release nanoparticles of clarithromycin in order to improve its therapeutic effect and reducing dosing frequency and its dose related side effects. Clarithromycin containing chitosan nanoparticles were prepared by ionotropic gelation method. The result showed that this method is reproducible easy and led to the efficient entrapment. Formulation had spherical particles in the particle range from 100 - 1500nm. Some process variables like effect of chitosan concentration, TPP concentration, acetic acid concentration were also evaluated with respect to drug content and encapsulation efficiency. The maximum encapsulation efficiency and drug content were 67.43 % and 6.13. The sustained release behavior of chitosan nanoparticles were evaluated both in phosphate buffer saline and simulated gastric fluid and results revealed that clarithromycin loaded chitosan nanoparticles are most suitable mode of delivery of drug for promising therapeutic action.