Pharmacological Evaluation of Antiulcer activity and potential mechanism of action of ethanolic extract of rhizome of kutaki (Picrorhiza kurroa)

Abstract

HPLC was performed to evaluate the rhizome in order to verify the chemical composition of the Picrorhiza kurooa rhizome extract. Based on the acute toxicity research in Wister rats, which were used in this examination, the ability to provide stomach protection was examined at various dosages of 1, 5, 10, 15, and 50 mg/kg. The degree of gastric protection was determined using a number of metrics, including stomach volume, pH, total acidity, free acidity, ulcer index, and % inhibition of ulceration. The preferred drug was ranitidine Picrorhiza kurrooa ethanolic extracts 20 mg/kg reduced stomach volume, total acidity, and free acidity significantly (P< 0.001). However, with a dosage of 50 mg/kg, the pH of the gastric juice rose considerably (P<0.001). A substantial (P< 0.001) reduction in the number of ulcers was also observed. As a result, phytochemicals such flavonoids, saponins, alkaloids, and tannins found in plant extracts may be responsible for the extracts' antiulcer actions.