Evaluation of antiulcer activity on roots of Picrorhiza kurroa by usingPyloric ligation rat models

Abstract

In order to confirm the chemical contents of Picrorhiza kurooa rhizome extract, HPLC was used to analyse the rhizome. The capacity to give stomach protection was investigated at various dosages of 1, 5, 10, 20, and 50 mg/kg determined based on the acute toxicity research in Wister rats, which were used in this investigation. Several metrics, such as stomach volume, pH, total acidity, free acidity, ulcer index, and percentage inhibition of ulceration, were used to gauge the degree of gastric protection. The medicine of choice was ranitidine. Picrorhiza kurrooa ethanolic extracts 20 mg/kg reduced stomach volume, total acidity, and free acidity significantly (P< 0.001). However, with a dosage of 50 mg/kg, the pH of the gastric juice rose considerably (P<0.001). A substantial (P< 0.001) reduction in the number of ulcers was also observed. As a result, phytochemicals such flavonoids, saponins, alkaloids, and tannins found in plant extracts may be responsible for the extracts' antiulcer actions.