Development and evaluation of floating pulsatile multiparticulate drug delivery system using aceclofenac as a model drug

Abstract

Development and evaluation of floating, pulsatile, multiparticulate drug delivery system   using aceclofenac as a model drug. Pulsatile drug delivery systems are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. Diseases wherein PDDS are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia. Dispersion technique was used for the preparation of beads of aceclofenac by using polymer of low methoxylated pectin, sodium alginate and gellan gum and combination of them. The active component was characterized using modern techniques like UV, IR, and DSC etc. The present study is aimed to develop floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy in arthritis. Cross-linked beads were prepared by using low methoxylated pectin, sodium alginate, low methoxylated pectin + Sodium alginate and low methoxylated pectin + deacetylated gellan by acid- base reaction during ionotropic gelation. Beads were dried in oven at 500 ^oC for 4hr. Aceclofenac was used as a model drug for encapsulation. Drug loaded multiparticulates were subjected to various characterization and evaluation parameters like entrapment efficiency, buoyancy study, surface topography.From the above evaluation studies, low methoxylated beads contain high entrapment efficiency with about 90% drug release. This optimized batch (F6) was kept for stability studies at 40°C ± 5°C and 75% RH ± 5% RH for 30 days in order to know the influence of temperature and relative humidity on drug content and drug release profile.