Formulation and evaluation of repaglinide microspheres

Abstract

The present investigation involves formulation and evaluation of microspheres with Repaglinide as model drug for prolongation of drug release time. An attempt was made to prepare microspheres of Repaglinide by Quasi emulsion solvent diffusion technique, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into systemic circulation. The microspheres were formulated by using various concentration of HPMCP, Ethyl cellulose and Eudragit RSPO as a retarding agent to control the release rate. The prepared microspheres were evaluated for Flow behavior, Compatibility study, Drug Entrapment Efficiency, In-vitro Dissolution, Scanning Electron Microscopy and Particle size analysis. Among the nine formulations prepared and evaluated F₁ and F₉ are found to show retarded release. In-vitro release studies indicated that, as the concentration of retarding agent (HPMCP, Eudragit and Ethyl cellulose) increases the formulation become more sustained.