Formulation and In Vitro evaluation of sustained release microspheres of aceclofenac

Abstract

The objective of the present study was preparation and invitro evaluation of sustained release microspheres of aceclofenac. Generally administration of microspheres will provide the localization of active substance at the site of action for prolonged period of the time. The microspheres of aceclofenac was prepared by emulsion cross linking method and solvent evaporation technique by using different grades of  gelatin with varying  concentrations and Eudragit (S-100,L-100) polymers respectively. The formulations were evaluated for particle size distribution analysis, flow properties like Angle of repose, bulk density, tapped density, true density, Hausner’s Ratio, Carr’s index, microencapsulation efficiency, Scanning electron microscopy(SEM) and invitro release studies. The optimized formulation showed good invitro sustained release activity of the drug Aceclofenac.