Preparation and characterization of doxorubicin HCl loaded chitosan nanoparticles by w/o emulsion method

Abstract

Polymeric nanoparticles are recently more investigated for controlled and targeted drug delivery. The aim of this study was to prepare and evaluate chitosan nanoparticles containing doxorubicin by w/o emusion method. SEM indicated spherical structure of nanoparticle without agglomeration. FTIR spectra indicated no chemical interaction between drug and polymer. In vitro drug release study suggests sustain drug release for longer period of time. Vigorous agitation leads to formation of smaller particle which lies in nano size and its drug release study confirms its sustained release.