Development, characterization and evaluation of mucoadhesive microspheres of amoxicillin trihydrate

Abstract

Mucoadhesive microspheres include microparticles and microcapsules (having a core of the drug) of 1-1000µm in diameter and consisting either entirely of a mucoadhesive polymer or having an outer coating of it, respectively. Amoxicillin microspheres were formulated by using solvent evaporation technique. Using Eudragit RS 100 as matrix polymer. Evaluation of the Prepared Mucoadhesive Microspheres done for % yield,  Particle size analysis, Particle size distribution Angle of repose, Determination of drug content, Shape and surface characterization, drug entrapment and finally cumulative drug release from microspheres.