Development Formulation and Evaluation of Sustained Release Matrix Tablets of Cefixime

Abstract

The objective of present work was to design sustained release matrix tablets of cefixime trihydrate to achieve a controlled and sustained drug release with reduced frequency of drug administration, reduced side effects and patient compliance. Matrix tablets of cefixime were prepared by using polymers like hydroxypropylmethylcellulose, Na CMC, Lactose monohydrate and different diluents. Cefixime sustained release tablets were prepared by direct compression method. The powder blend was subjected for pre compressional parameters such as tapped density, bulk density, angle of repose, compressibility index and hausner ratio. The drug polymer interaction was checked by comparing the IR spectra of the physical mixture of drug and IR spectrum of pure drug. The prepared tablets were evaluated to post compressional parameters such as hardness, friability, average weight, uniformity of weight and in-vivo dissolution study. Amongst all formulations, the release profile of F2 gave optimum results. It was concluded that all formulations followed zero order with non-fickian diffusion method.