Application and advancement of microsphere as controlled delivery system: A review

Abstract

Of late researchers have been striving hard to scale the requirements to formulate an effective dosage form to simulate controlled drug release. Microspheres have been proved to be a suitable bridge to scale this distance. Microsphere are free flowing solid particle made up of  biodegradable and non-biodegradable components, ideally having a particle size less than 200 µm and can be injected by an 18 or 20 number needle. They can be delivered through various routes like oral, nasal, colonal, parentally, opthalmic and transdermal etc. Various recent advancements like hollow, magnetic, microballons, floating microsphers have been contributed emensely to improve the various hinderances associated with the use of microsphers,which include site specific targeting and improved release kinetics. Current review describes the recent advancements that have been undertaken in the field of microspheres to achive the controlled drug release, with pre-determined drug release kinetics. Author belives that the review will prove a silver lining for the aspiring researchers, thus helping them to contribute their brick in the castle entitlled “microspheres”.