Evaluation of Hepatoprotective activity of Leaves of Abutilon indicum (L.) Sweet against Paracetamol induced Liver toxicity in Albino rats

Abstract

Liver disease refers to a range of conditions that cause harm to the human liver's tissues, structures, and cells. The liver performs numerous vital tasks, making it prone to errors. One of the most prevalent causes of liver illness is inflammation, which is frequently caused by alcohol, a poor diet, or starvation. Drug-induced liver injury or failure is a major public health issue that affects not only medical professionals, but also the pharmaceutical business and the Drug Control Board. According to the American Acute Liver Failure Study Group, more than half of acute liver failure patients contain idiosyncratic liver injury induced by other medicines, such as paracetamol overdose (39%). The present study investigates the hepatoprotective activity of a ethyl acetate extract of Abutilon indicum (Leaves) against paracetamol-induced liver damage in albino rats. The results reveal that the ethyl acetate extract had considerable hepatoprotective action when compared to the hepatotoxic control at a dosage of 250 mg/kg.