Evaluation of Wound Healing Activity of Syzygium cumini root extract in rats

Abstract

Plants and their extracts have immense potential for the management and treatment of wounds. The phyto-medicines for wound healing are not only cheap and affordable but are also safe as hypersensitive reactions are rarely encountered with the use of these agents 2. These natural agents induce healing and regeneration of the lost tissue by multiple mechanisms. However, there is a need for scientific validation, standardization and safety evaluation of plants of the traditional medicine before these could be recommended for healing of the wounds. In ayurvedic treatment, a medicine consists of plant products, either single drug or in combination with others (polyherbal formulation), which are considered to be less toxic and free from side effects are used as wound healing agents. On review of literature it was found that the plant Syzygium cumini, Linn is traditionally being used in treatment of wound. Hence, the present work was attempted to scientifically validate the traditional claim, by using experimental animal models. The aim of present study was to evaluate the wound healing activity of Syzygium cumini, Linn root extract in Excision, Incision and dead space wound models in rats.