Microneedle Patch:An Approachto Enhance Systemic Delivery of Drugs Through the Skin

Abstract

Transdermal administration offers the benefit of avoiding the first-pass impact and enabling continuous medication release. The largest obstacle to transdermal distribution, however, is the fact that only a small number of strong medications with optimal physicochemical characteristics can pass through skin barriers, intercellularly penetrate, and attain therapeutic concentration through this mechanism. One strategy for achieving high patient compliance is microneedle medication administration. The use of microneedles improves medication administration by this method and helps to solve a number of issues with traditional formulations. One of the microscale physical enhancement techniques that significantly broadens the range of medications available for transdermal and intradermal administration is the use of microneedles. The main idea is that the skin layer is disrupted, which opens up micron-sized passageways that carry the medication straight to the upper dermis or epidermis, where it can enter the systemic circulation without having to pass through the barrier. The design of the microneedles and the drug compositions can regulate the dosage, rate of distribution, and effectiveness of the medications. The types of microneedles, their designs, the materials utilised in their construction, and their production processes are all introduced in this review.